Maija Dambrova Selected Research

3-(2,2,2-trimethylhydrazine)propionate

12/2021	Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.
11/2016	Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
1/2014	Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.
10/2013	Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis.
6/2012	The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
9/2011	Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats.
5/2011	Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.
1/2011	Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
9/2010	Mildronate exerts acute anticonvulsant and antihypnotic effects.
8/2009	Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.

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Maija Dambrova Research Topics

Disease

10	Infarction (Infarctions) 12/2021 - 06/2002
10	Ischemia 01/2021 - 06/2002
7	Insulin Resistance 03/2022 - 11/2016
7	Inflammation (Inflammations) 12/2021 - 12/2005
7	Type 2 Diabetes Mellitus (MODY) 12/2020 - 08/2009
5	Myocardial Infarction 01/2021 - 08/2009
5	Hypoxia (Hypoxemia) 01/2021 - 01/2014
5	Atherosclerosis 11/2016 - 01/2009
5	Encephalitis (Encephalitis, Rasmussen) 04/2010 - 12/2005
4	Pain (Aches) 03/2021 - 10/2006
4	Seizures (Absence Seizure) 01/2021 - 09/2010
4	Reperfusion Injury 01/2021 - 08/2009
4	Hyperglycemia 01/2021 - 05/2011
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 11/2014
4	Diabetes Complications 02/2013 - 08/2009
3	Heart Failure 12/2020 - 11/2016
3	Mitochondrial Diseases (Mitochondrial Disease) 12/2020 - 02/2017
3	Necrosis 10/2020 - 08/2009
3	Body Weight (Weight, Body) 01/2020 - 12/2007
3	Cardiac Arrhythmias (Arrythmia) 11/2016 - 06/2002
2	Traumatic Brain Injuries (Traumatic Brain Injury) 10/2021 - 01/2020
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 01/2017
2	Hyperlipidemias (Hyperlipidemia) 12/2020 - 05/2011
2	Glucose Intolerance 09/2017 - 05/2011
2	Weight Gain 01/2017 - 05/2011
2	Obesity 01/2017 - 05/2011
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/2016 - 09/2011
2	Brain Ischemia (Cerebral Ischemia) 11/2016 - 09/2011
2	Atherosclerotic Plaque (Atheroma) 09/2015 - 01/2009
2	Hypertension (High Blood Pressure) 01/2014 - 01/2011
2	Coronary Occlusion 08/2009 - 06/2002
1	Adenocarcinoma 01/2022
1	Ventricular Dysfunction 12/2021
1	COVID-19 12/2021
1	Pulmonary Hypertension 12/2021
1	Hypertrophy 12/2021
1	Left Ventricular Dysfunction 12/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021
1	Fever (Fevers) 03/2021
1	Breast Neoplasms (Breast Cancer) 12/2020
1	Hydronephrosis 11/2020
1	Acute Kidney Injury (Acute Renal Failure) 11/2020

Drug/Important Bio-Agent (IBA)

14	3-(2,2,2-trimethylhydrazine)propionateIBA 12/2021 - 08/2002
14	Carnitine (L-Carnitine)FDA LinkGeneric 11/2020 - 12/2006
10	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 08/2009
9	Glucose (Dextrose)FDA LinkGeneric 03/2022 - 08/2009
8	acylcarnitineIBA 12/2021 - 09/2015
6	Pharmaceutical PreparationsIBA 12/2021 - 10/2006
6	trimethyloxamine (trimethylamine N-oxide)IBA 01/2020 - 10/2013
5	4-amino-3-phenylbutyric acid (phenibut)IBA 09/2020 - 03/2008
5	MelanocortinsIBA 01/2010 - 01/2004
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2017
4	Insulin (Novolin)FDA Link 06/2021 - 01/2014
4	Peptides (Polypeptides)IBA 01/2020 - 01/2004
4	Blood Glucose (Blood Sugar)IBA 01/2017 - 08/2009
4	Melanocortin Receptors (Melanocortin Receptor)IBA 01/2010 - 12/2005
3	LigandsIBA 10/2021 - 01/2010
3	Pyruvic Acid (Pyruvate)IBA 01/2021 - 10/2020
3	SaltsIBA 12/2020 - 08/2009
3	LipopolysaccharidesIBA 10/2020 - 12/2007
3	methyl-gamma-butyrobetaineIBA 08/2017 - 09/2015
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2010 - 06/2006
3	1- (3,4- dimethoxy- 2- - chlorobenzylideneamino)guanidineIBA 04/2010 - 06/2002
2	Neuroprotective AgentsIBA 10/2021 - 11/2016
2	Sigma-1 ReceptorIBA 10/2021 - 01/2017
2	imidazole mustard (BIC)IBA 01/2021 - 01/2017
2	Pentylenetetrazole (Metrazol)IBA 01/2021 - 10/2015
2	LipidsIBA 12/2020 - 01/2019
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 10/2020 - 04/2010
2	Interleukin-1beta (Interleukin 1 beta)IBA 10/2020 - 04/2010
2	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 05/2011
2	Dizocilpine Maleate (Dizocilpine)IBA 12/2019 - 10/2019
2	PalmitoylcarnitineIBA 09/2017 - 01/2016
2	Apolipoproteins E (ApoE)IBA 09/2015 - 01/2009
2	gamma-butyrobetaine (butyrobetaine)IBA 09/2015 - 12/2006
2	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 06/2013 - 06/2012
2	EnzymesIBA 05/2013 - 03/2011
2	NF-kappa B (NF-kB)IBA 04/2010 - 12/2005
2	beta-MSHIBA 10/2006 - 12/2005
2	Guanidine (Guanidine Nitrate)FDA Link 08/2004 - 06/2002
1	Ketone BodiesIBA 03/2022
1	Insulin-Like Growth Factor I (IGF-1)IBA 03/2022
1	C-PeptideIBA 03/2022
1	CytokinesIBA 03/2021
1	NADPH Oxidase 2IBA 01/2021
1	HexokinaseIBA 01/2021
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2021
1	Succinic Acid (Succinate)IBA 01/2021
1	BicucullineIBA 01/2021
1	itaconic acidIBA 01/2021
1	GABA-B ReceptorsIBA 01/2021
1	Sodium-Glucose Transport ProteinsIBA 12/2020
1	empagliflozinIBA 12/2020
1	Sodium-Glucose Transporter 2 InhibitorsIBA 12/2020
1	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (FCCP)IBA 11/2020
1	Furosemide (Lasix)FDA LinkGeneric 11/2020
1	Glutamic Acid (Glutamate)FDA Link 11/2020

Therapy/Procedure

2	Therapeutics 12/2020 - 01/2020
1	Traditional Medicine (Folk Remedies) 03/2021
1	Drug Therapy (Chemotherapy) 11/2020